A Review Of pentobarbital sodium use
A Review Of pentobarbital sodium use
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pentobarbital decreases effects of sufentanil SL by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Intently. Coadministration of CYP3A4 inducers may possibly reduce sufentanil ranges and efficacy, potentially precipitating withdrawal syndrome in sufferers who've designed physical dependence to sufentanil. Discontinuation of concomitantly used CYP3A4 inducers may perhaps raise sufentanil plasma concentration.
pentobarbital will minimize the extent or effect of ibuprofen by impacting hepatic enzyme CYP2C9/ten metabolism. Minimal/Significance Unidentified.
pentobarbital decreases levels of vandetanib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Avoid coadministration with potent CYP3A4 inducers; these drugs reduce exposure to vandetanib by approximately forty%.
pentobarbital will lower the extent or effect of fedratinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Effect of coadministering a solid CYP3A4 inducer with fedratinib hasn't been examined.
Phenytoin, sodium valproate, valproic acid: The effect of barbiturates around the metabolism of phenytoin seems for being variable. Some investigators report an accelerating effect, even though others report no effect. Because the effect of barbiturates over the metabolism of phenytoin isn't predictable, phenytoin and barbiturate blood amounts really should be monitored a lot more commonly if these drugs are presented concurrently.
pentobarbital will decrease the extent or effect of maraviroc by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
pentobarbital will reduce the extent or effect of abiraterone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
pentobarbital will minimize the extent or effect of fostemsavir by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
pentobarbital will lower the extent or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
Slight (one)pentobarbital here will minimize the level or effect of paclitaxel protein sure by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unidentified.
pentobarbital will reduce the level or effect of fosaprepitant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
pentobarbital will lessen the level or effect of nimodipine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Not known.
Watch Carefully (one)pentobarbital will lower the level or effect of glecaprevir/pibrentasvir by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
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